Multifocal Electroretinogram in Rhodopsin P347L Transgenic Pigs
نویسندگان
چکیده
منابع مشابه
Multifocal electroretinogram in rhodopsin P347L transgenic pigs.
PURPOSE Neural ectopic rewiring in retinal degeneration such as retinitis pigmentosa (RP) may form functional synapses between cones and rod bipolar cells that cause atypical signal processing. In this study, the multifocal electroretinograms (mfERGs) of a large animal model of RP, the rhodopsin P347L transgenic (Tg) pig, were measured to examine the sources and nature of altered signal process...
متن کاملTranscorneal electrical stimulation promotes survival of photoreceptors and improves retinal function in rhodopsin P347L transgenic rabbits.
PURPOSE To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on the photoreceptors, and whether it slows the rate of decrease of the electroretinogram (ERG) in rhodopsin P347L transgenic (Tg) rabbits. METHODS Six-week-old Tg rabbits received TES through a contact lens electrode on the left eye weekly for 6 weeks. The right eyes received sham stimulation o...
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PURPOSE To investigate early changes of retinal function in myopic eyes, patients with various degrees of myopia underwent multifocal electroretinography (multifocal ERG). METHODS Thirty young patients (mean age, 26.1 years) were divided into three groups according to the degree of refractive error: emmetropia/low, medium, and high myopia. All groups were matched by sex and age. All subjects ...
متن کاملEarly loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina.
Retinitis pigmentosa (RP), a type of retinal degeneration involving first rod and then slow cone photoreceptor degeneration, can be caused by any of a number of mutations in different genes. In the cases of mutations affecting rod-specific genes such as rhodopsin, it is unclear how the mutations may cause degeneration of cones. We have used the porcine retina, which is rod-dominated and has an ...
متن کاملMultifocal electroretinogram in birdshot chorioretinopathy.
PURPOSE To characterize multifocal electroretinogram parameters in patients with birdshot chorioretinopathy. METHODS Twenty-eight patients with birdshot chorioretinopathy consecutively included from 2006 to 2011 were matched to 27 healthy subjects for age, axial length, and lens status. Multifocal electroretinogram was prospectively evaluated using the Vision Monitor system. RESULTS Birdsho...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2008
ISSN: 1552-5783
DOI: 10.1167/iovs.07-1159